ZESTRIL

SPECIFICATION

5mg , 10mg , 20mg

Generics

Lisinopril

About

Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide, angiotensin II. Whilst mechanism through which lisinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system. Lisinopril is antihypertensive even in patients with low-renin hypertension.

Indication

Lisinopril is indicated for: Hypertension : The treatment of hypertension.Heart failure : The treatment of symptomatic heart failure. Acute myocardial infarction.

Side Effects

Common: Dizziness, headache, orthostatic effects (including hypotension), cough, diarrhea, nausea, vomiting.

Drug Interactions

Diuretics , Potassium supplements, potassium-sparing diuretics (e.g. spironolactone, triamterene or amiloride) or potassium-containing salt substitutes, Lithium , NSAIDs and ACE inhibitors , glyceryl trinitrate and other nitrates , tricyclic antidepressants and antipsychotics , Sympathomimetics , antidiabetic medicines (insulins, oral hypoglycemic agents ) 

When not to Use

Lisinopril is contraindicated in patients:- With hypersensitivity to lisinopril, to any of the excipients or any other angiotensin converting enzyme (ACE) inhibitor.- With a history of angioedema associated with previous ACE inhibitor therapy.- With hereditary or idiopathic angioedema.- Who are pregnant .

Precaution

Lisinopril therapy should be immediately discontinued in patients presenting with angioedema; appropriate anti-histamine/corticosteroid therapy and monitoring should be provided until complete and sustained resolution of all signs and symptoms has occurred.