VELOSEF

SPECIFICATION

250mg , 500mg

Generics

Cephradine

About

Cephradine inhibits the final transpeptidation step of the peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillinbinding proteins (PBPs), thus arresting cell wall synthesis leading to bacterial cell death.

Indication

Cephradine is indicated in the treatment of following infections:Upper respiratory tract infections: Sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis and otitis media.Lower respiratory tract infections: Acute and chronic bronchitis, lobar and bronchopneumonia.Skin and soft tissue infections: Impetigo, abscess, cellulitis and furunculosis. Urinary tract infections: Cystitis, urethritis and pyelonephritis.Gastrointestinal tract infections: Bacillary dysentery, enteritis and peritonitis

Dosage

FOR ADULTS CAPSULE TWICE DAILY.

Gastrointestinal: Glossitis, nausea, vomiting, diarrhea or loose stools, tenesmus, abdominal paincolitis and pseudomembranous colitis. Hypersensitivity: Mild urticaria or skin rash, edema, erythema, pruritis, joint pain and drug fever. Hematologic: Mild, transient eosinophilia, leukpenia and neutropenia. Other: Headache, dizziness, dyspnea, paresthesia, candidal overgrowth and vaginitis.

Drug Interactions

Loop diuretics , probenecid , aminoglycosides , anticoagulants.

When not to Use

Cephradine is contraindicated in patients with known hypersensitivity to cephradine or to any excipient of the product.

Precaution

Cephalosporins should be given with caution to penicillin-sensitive patients, as there is some evidence of partial cross-allergenicity between the penicillins and cephalosporins. Patients have had severe reactions (including anaphylaxis) to both drugs.