OXIDIL (IM 250mg)

SPECIFICATION

IM 250MG

Generics

Ceftriaxone Sodium

About

Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. By binding to these enzymes, Ceftriaxone results in the formation of defective cell walls and cell death.

Indication

It is indicated for the treatment of the following infections due to susceptible organisms. Such infections include: Lower respiratory tract infections Acute bacterial otitis media Skin and skin structure infections Urinary tract infections (complicated and uncomplicated etc.

Side Effects

Hypersensitivity reactions such as allergic skin reactions and anaphy lactic reactions, secondary infections with yeast, fungi or resistant organisms as well as changes in blood cell counts.Mycosis of the genital tract, neutropenia, leucopenia, eosinophilia, thrombocytopenia, anaemia (including haemolytic anaemia), slight prolongation of prothrombin time, anaphy lactic (e.g. bronchospasm) and anaphy lactoid reactions, headache, dizziness, Increase in serum liver enzymes (AST, ALT, alkaline phosphatase), rigors and pyrexia.

Drug Interactions

Calcium containing IV solutions , oral hormonal contraceptives.

When not to Use

Ceftriaxone is contraindicated in patients with:- Hypersensitivity to ceftriaxone or to any of the cephalosporins.- Previous immediate and/or severe hypersensitivity reaction to penicillin or to any other type of beta-lactam drug.- Premature newborns up to a corrected age of 41 weeks (weeks of gestation + weeks of life) .

Precaution

Before therapy with ceftriaxone is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporins, Penicillins or other drugs.