LASIX

SPECIFICATION

20mg , 40mg

Generics

Furosemide

About

It has been demonstrated that Furosemide inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of Henle. The high degree of efficacy is largely due to the unique site of action. The action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone.

Indication

Fluid retention associated with chronic congestive cardiac failure (if diuretic treatment is required.Fluid retention associated with acute congestive cardiac failure. Fluid retention associated with chronic renal failure. Maintenance of fluid excretion in acute renal failure, including that due to pregnancy or burns.  Fluid retention associated with nephrotic syndrome (if diuretic treatment is required). Fluid retention associated with liver disease (if necessary to supplement treatment with aldosterone antagonists). Hypertension.  Hypertensive crisis (as a supportive measure).  Support of forced diuresis.

Side Effects

Gastrointestinal System Reaction : Hepatic encephalopathy in patients with oral and gastric irritation hepatocellular insufficiency , cramping , pancreatitis , diarrhea , jaundice (intrahepatic cholestatic jaundice) , constipation , increased liver enzymes , nausea , anorexia , vomiting ; Systemic Hypersensitivity Reactions.

Drug Interactions

Aminoglycoside antibiotics , ethacrynic acid , cisplatin , tubocurarine , Lithium , angiotensin converting enzyme inhibitors or angiotensin II receptor blockers , norepinephrine , sucralfate , Phenytoin , Methotrexate , cephalosporin , cyclosporine .

When not to Use

In patients with hypersensitivity to furosemide or any of the excipients . Patients allergic to sulfonamides (e.g. sulfonamide antibiotics or sulfonylureas) may show crosssensitivity to furosemide .  In patients with hypovolaemia or dehydration.  In patients with anuric renal failure not responding to frusemide. In patients with severe hypokalaemia  In patients with severe hyponatraemia .

Precaution

In patients with partial obstruction of urinary outflow (e.g in patients with bladder – emptying disorders, prostatic hyperplasia, narrowing of the urethra) increased production of urine may provoke or aggravate complaints. Thus, these patients require careful monitoring - especially during the initial stages of treatment.