Description
Description
SPECIFICATION
50Mg 20S
Generics
Diclofenac potassium
About
Diclofenac has analgesic, anti-inflammatory, and antipyretic properties.The mechanism of action of diclofenac , like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro. Diclofenac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because diclofenac is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Indication
It is used to treat pain and inflammation.
Side Effects
These uncommon side effects may affect between 1 and 10 in every 1000 patients, especially when taking a high daily dose (150 mg) for a long period of time : Sudden and oppressive chest pain (signs of myocardial infarction or heart attack) , Breathlessness, difficulty of breathing when lying down, swelling of the feet or legs (signs of cardiac failure).These rare or very rare side effects may affect from less than 1 to 10 in every 10,000 patients : Spontaneous bleeding or bruising (signs of thrombocytopenia) , High fever, frequent infections, persistent sore throat (signs of agranulocytosis) , Difficulty of breathing or swallowing, rash, itching, hives, dizziness (signs of hypersensitivity, anaphylactic and anaphylactoid reactions) , Swelling mainly of the face and throat (signs of angioedema ) , Disturbing thoughts or moods (signs of psychotic disorders) , Impaired memory (signs of memory impairment) , Seizures (signs of convulsions) , Anxiety , Stiff neck, fever, nausea, vomiting, headache (signs of aseptic meningitis). These side effects may affect between 1 and 10 in every 100 patients : Headache, dizziness, vertigo, nausea, vomiting, diarrhea, indigestion (signs of dyspepsia), abdominal pain, flatulence, loss of appetite (signs of decreased appetite), abnormal liver function test results (e.g. level of transaminases increased), skin rash, skin reaction such as redness or swelling at the site of injection.
Drug Interactions
Lithium or selective serotonin-reuptake inhibitors (SSRIs) , Digoxin , Diuretics , ACE inhibitors or beta-blockers , acetylsalicylic acid or ibuprofen , Corticosteroids , Blood thinners ,Medicines used to treat diabetes, except insulin , Methotrexate , Ciclosporin, Tacrolimus , Trimethoprim , Quinolone antibacterials , Voriconazole , Phenytoin.