Description
Description
SPECIFICATION
250mg & 500mg
Generics
Cephalexin
About
Cephalexin is an oral broad-spectrum antibiotic. In adequate concentrations it is bactericidal for sensitive proliferating microorganisms by inhibiting the biosynthesis of the cell wall.
Indication
It is indicated for treatment of respiratory tract infections (RTIs), urinary tract infections (UTIs), skin and soft tissue infections, otitis media and other infections due to sensitive organisms.
Dosage
FOR ADULTS TWICE DAILY.
Side Effects
It is generally well-tolerated. The common side effects are gastrointestinal disturbances (diarrhoea), hypersensitivity reactions (skin rashes). Other side effects are nausea and vomiting. Other reactions reported rarely are genital pruritus, genital moniliasis, vaginitis. Sometimes it causes anaphylaxis, erythema multiforme, toxic epidermal necrolysis, fever, abdominal pain, super infection, renal dysfunction, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, and hemorrhage. Several cephalosporins have been implicated triggering seizures, particularly in patients with renal impairment .
Drug Interactions
Bacteriostatic antibiotics , Uricosuric drugs (e.g. probenecid) , Metformin , ethacrynic acid, furosemide , aminoglycosides, polymyxin, colistin , Oral anticoagulants , Typhoid vaccine , Oral contraceptives , Cytotoxic drugs.
When not to Use
Cephalexin is contraindicated in patients with known allergy to the cephalosporin group of antibiotics. Severe systemic infections, which require parenteral cephalosporin treatment, should not be treated orally during the acute stage.
Precaution
Cephalosporins should be given with caution to penicillin-sensitive patients, as there is some evidence of partial cross-allergenicity between the penicillins and cephalosporins. Patients have had severe reactions (including anaphylaxis) to both drugs.