ZESTORETIC

SPECIFICATION

12.5/20Mg

Generics

Lisinopril Dihydrate , Hydrochlorothiazide

About

Lisinopril : The mechanism through which lisinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system. Lisinopril is antihypertensive even in patients with low-renin hypertension. Hydrochlorothiazide : The mechanism of the antihypertensive effect of thiazides is unknown. Thiazides do not usually affect normal blood pressure. Hydrochlorothiazide is a diuretic and antihypertensive. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume with consequent increase in plasma renin activity increase in aldosterone secretion, increases in urinary potassium loss and decrease in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so co-administration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with these diuretics .

Indication

It is indicated in the management of mild to moderate hypertension in patients who are not adequately controlled on monotherapy.

Side Effects

It is indicated in the management of mild to moderate hypertension in patients who are not adequately controlled on monotherapy.

Drug Interactions

Agents Increasing Serum Potassium , Agents Affecting Sympathetic Activity , Lithium , Corticosteroids (ACTH) , Nonsteroidal Anti-inflammatory Drugs , Tubocurarine , Insulin , Alcohol, Barbiturates or Narcotics , Pressor Amines .

When not to Use

Lisinopril+Hydrochlorothiazide is contraindicated in patients who are hypersensitive to any component of this product and in patients with a history of angioneurotic edema relating to previous treatment with an angiotensin-converting enzyme inhibitor and in patients with hereditary or idiopathic angioedema. - Lisinopril+Hydrochlorothiazide is contraindicated in patients who are hypersensitive to other sulphonamide-derived drugs. - Lisinopril+Hydrochlorothiazide is contraindicated in patients with anuria. - Lisinopril+Hydrochlorothiazide is contraindicated in pregnancy and treatment should be stopped if pregnancy is suspected.

Precaution

As with all antihypertensive therapy, symptomatic hypotension may occur in some patients. Periodic determination of serum electrolytes should be performed at appropriate intervals in such patients. In patients at increased risk of symptomatic hypotension, initiation of therapy and dose adjustment should be monitored under close medical supervision .