ZINACEF

SPECIFICATION

250MG

Generics

Cefuroxime Sodium

About

Cefuroxime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefuroxime has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases of Gram-negative and Gram-positive bacteria.

Indication

It is indicated for treatment of respiratory tract infections (RTIs), urinary tract infections (UTIs), skin and soft tissue infections, otitis media and other infections due to sensitive organisms.

Dosage

According to severity of infection.

Side Effects

Blood and lymphatic system disorders : Common Neutropenia, eosinophilia. Uncommon : Leukopenia, decreased haemoglobin concentration, positive Coomb’s test. Rare Thrombocytopenia . Very rare Haemolytic anaemia. Immune system disorders Hypersensitivity reactions including Uncommon Skin rash, urticaria and pruritus. Rare Drug fever. Very rare Interstitial nephritis, anaphylaxis, cutaneous vasculitis. Gastrointestinal disorders Uncommon Gastrointestinal disturbance. Very rare Pseudomembranous colitis . Hepatobiliary disorders Common Transient rise in liver enzymes. Uncommon Transient rise in bilirubin.

Drug Interactions

Slight interference with copper reduction methods (Benedict’s, Fehling’s, Clinitest) may be observed. However, this should not lead to false-positive results, as may be experienced with some other cephalosporins , oral contraceptives .

When not to Use

Hypersensitivity to cephalosporin antibiotics.

Precaution

As with other antibiotics, use of Cefuroxime may result in the overgrowth of Candida. Prolonged use may also result in the overgrowth of other non-susceptible organisms (e.g. enterococci and Clostridium difficile), which may require interruption of treatment.