TANZO (2.25)

SPECIFICATION

IV 2.25 G

Generics

Piperacillin , Tazobactam

About

Piperacillin belongs to the group of medicines known as “broad-spectrum penicillin antibiotics”. It can kill many kinds of bacteria. Tazobactam can prevent some resistant bacteria from surviving the effects of piperacillin. This means that when piperacillin and tazobactam are given together, more types of bacteria are killed.

Indication

It is used in adults and adolescents to treat bacterial infections, such as those affecting the lower respiratory tract (lungs), urinary tract (kidneys and bladder), abdomen, skin or blood. It may be used to treat bacterial infections in patients with low white blood cell counts (reduced resistance to infections).

Side Effects

Very common side effects (may affect more than 1 in 10 people): - Diarrhoea . Common side effects (may affect up to 1 in 10 people): - Yeast infection - decrease in platelets, decrease of red blood cells or blood pigment / haemoglobin, abnormal lab test (positive direct Coombs), prolonged blood clotting time (activated partial thromboplastin time prolonged) - decrease in blood protein - headache, sleeplessness - abdominal pain, vomiting, nausea, constipation, upset stomach - increase in blood liver enzymes - skin rash, itching - abnormal kidney blood tests - fever, injection site reaction . Uncommon side effects (may affect up to 1 in 100 people): - Decrease in white blood cells (leukopenia), prolonged blood clotting time (prothrombin time prolonged) - decreased blood potassium, decreased blood sugar.

Drug Interactions

Probenecid , Heparin, warfarin or aspirin , methotrexate , tobramycin, gentamicin or vancomycin.

When not to Use

Do not use If you are allergic to piperacillin or tazobactam or any of the other ingredients of this medicine . If you are allergic to antibiotics known as penicillins, cephalosporins or other beta-lactamase inhibitors, as you may be allergic to this medicine.

Precaution

Serious and occasionally fatal hypersensitivity (anaphylactic/anaphylactoid including shock) reactions have been reported in patients receiving therapy with penicillins. These reactions are more apt to occur in persons with a history of penicillin hypersensitivity or sensitivity to multiple allergens.