HUMULIN R

SPECIFICATION

100I.U/Ml 10Ml

Generics

Human Insulin

About

The major effects of insulin on carbohydrate homoeostasis following its binding to specific cell-surface receptors on insulin-sensitive tissues, notably the liver, muscles and adipose tissue. It inhibits hepatic glucose production and enhances peripheral glucose disposal thereby reducing blood-glucose concentration. It also inhibits lipolysis thereby preventing the formation of ketone bodies.

Indication

It is indicated for the treatment of : Patients with Type I diabetes mellitus. - Patients with Type II diabetes mellitus either alone or in combination with oral anti-diabetic agents. - Patients with gestational diabetes. - The emergency management of diabetic ketoacidosis.

Dosage

According to HBA 1c level

Side Effects

Hypoglycemia : They may include cold sweat, cool pale skin, nervousness or tremor, anxious feeling, unusual tiredness or weakness, confusion, difficulty in concentration, headache, nausea and palpitation. Severe hypoglycemia may lead to unconsciousness and may result in temporary or permanent impairment of brain function or even death , Weight gain , Oedema and refraction anomalies , . Local hypersensitivity reactions (redness, swelling and itching at the injection site) .

Drug Interactions

Beta blocking agent Oral hypoglycemic agents (OHA), octreotide, monoamine oxidase inhibitor (MAOI), non selective beta blocking agents, angiotensin converting enzyme (ACE) inhibitors, salicylates, alcohol and alcohol steroids , Oral contraceptives, thiazides, glucocorticoids, thyroid hormones and sympathomimetics, danazol etc.

When not to Use

It is contraindicated in patients with: A personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) . Known hypersensitivity to semaglutide or to any of the product components .

Precaution

Care is also necessary during excessive exercise. Hypoglycemia caused by metabolic effects and increased insulin absorption is the usual response, but hyperglycemia may sometimes occur. Adjustment of insulin dosage may also be necessary if patients change their level of physical activity or change their usual diet.