KESTINE

SPECIFICATION

10Mg

Generics

Ebastine

About

Ebastine and its active metabolite, carebastine, are selective antihistamines acting on peripheral H1 receptors, which appear to have no sedative and anticholinergic side effects at the recommended doses.

Indication

Ebastine is indicated for the symptomatic treatment of: • Seasonal and perennial allergic rhinitis / rhinoconjunctivitis • Urticaria

Side Effects

Very Common: Headache. Common: Somnolence & dry mouth. Uncommon: Epistaxis, pharyngitis and rhinitis. Rare: Hypersensitivity reactions (such as anaphylaxis and angioedema), nervousness, insomnia, dysaesthesia, hypoaesthesia, dysgeusia, dizziness, tachycardia, palpitations, nausea, abdominal pain, dyspepsia, vomiting, hepatitis, cholestasis, abnormal liver function test (transaminases, gamma-GT, alkaline phosphatase and bilirubin increased), urticaria, rash, dermatitis, menstrual disorders, oedema & asthenia. Very rare: Exanthema, eczema and dysmenorrhoea.

Drug Interactions

Ketoconazole or Itraconazole and erythromycin , rifampicin

When not to Use

Ebastine is contraindicated:• In patients with known sensitivity to ebastine or to any excipient of the product.• In children under 12 years of age in the absence of efficacy and safety data.• In cases of phenylketonuria, due to the presence of aspartame..

Precaution

Ebastine should be used with caution in patients with severe hepatic impairment.