CEDROX BD

SPECIFICATION

500MG

Generics

Cefadroxil Monohydrate

About

Cefadroxil is a first-generation cephalosporin antibiotic. It is bactericidal, and acts by inhibiting synthesis of the bacterial cell wall. Bacterial cell wall is held rigid and protected against osmotic rupture by peptidoglycan. Cefadroxil inhibits the final cross linking stage of peptidoglycan production by binding to and inactivating transpeptidase, which is a penicillin binding protein on the inner surface of the bacterial cell membrane may result in overgrowth of non-susceptible organisms. Careful observation of the patients is essential. If super infection occurs during the therapy, appropriate measures should be taken.

Indication

Cefadroxil is indicated in the treatment of mild to moderate infections of the respiratory tract (Pharyngitis & tonsillitis), urinary tract, skin and skin structures and bone caused by susceptible organisms and as an alternative to penicillin in patients with a history of hypersensitivity reactions.

Dosage

FOR ADULTS TWICE DAILY.

Side Effects

It is generally well-tolerated. The common side effects are gastrointestinal disturbances (diarrhoea), hypersensitivity reactions (skin rashes). Other side effects are nausea and vomiting. Other reactions reported rarely are genital pruritus, genital moniliasis, vaginitis. Sometimes it causes anaphylaxis, erythema multiforme, toxic epidermal necrolysis, fever, abdominal pain, super infection, renal dysfunction, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, and hemorrhage. Several cephalosporins have been implicated triggering seizures, particularly in patients with renal impairment .

Drug Interactions

Anticoagulants , Carbamazepine , probenecid.

When not to Use

Contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Precaution

In patients with known or suspected renal impairment, careful clinical observation and appropriate laboratory studies should be made prior to and during the therapy.