ZAMLO

SPECIFICATION

5mg , Zamlo-h

Generics

Amlodipine Besylate

About

The mechanism of the antihypertensive action of amlodipine is due to direct relaxant effect on vascular smooth muscle. The precise mechanism by which amlodipine relieves angina has not been fully determined but amlodipine reduces total ischemic burden by the following two actions. Amlodipine dilates peripheral arterioles thus, reduces the total peripheral resistance (after load) against which the heart works.

Indication

Amlodipine Besylate is indicated for the first line treatment of hypertension and can be used as the sole agent to control blood pressure in the majority of patients.Amlodipine Besylate is indicated for the first line treatment of myocardial ischemia whether due to fixed obstruction (stable angina) and/ or vasospasm/vasoconstriction (prinzmetal’s or variant angina) of coronary vasculature.

Side Effects

Amlodipine Besylate is well tolerated; the most commonly observed side effects were headache, edema, fatigue, nausea, flushing and dizziness.

Drug Interactions

Azole antifungals , erythromycin , cyclosporins , sildenafil , rifampicin , dantrolene , simvastatin , tacrolimus , other antihypertensives , grape fruit juice.

When not to Use

Amlodipine Besylate is contraindicated in patients with a known hypersensitivity to dihydropyridines.

Precaution

Amlodipine Besylate used at similar doses in elderly or younger patients, is equally well tolerated. Therefore, normal dosage regimens are recommende