VEDICAR

SPECIFICATION

12.5mg , 25mg , 6.25mg , 3.125mg

Generics

Carvedilol

About

Carvedilol is a vasodilatory non-selective beta-blocker, which reduces the peripheral vascular resistance by selective alpha 1- receptor blockade and suppresses the renin-angiotensin system through non-selective beta-blockade. Plasma renin activity is reduced and fluid retention is rare.

Indication

It is used to treat angina (chest pain) and mild, moderate or severe heart failure. It is also used to treat high blood pressure (hypertension).

Side Effects

 Elevated cholesterol levels • Loss of control of blood sugar in people with diabetes • Depression, depressed mood • Visual disturbance • Reduced lacrimation, eye irritation • Slow heart rate • Oedema (swelling of the body or parts of the body), fluid overload, increased volume of blood in the body .

Drug Interactions

Diltiazem, verapamil or amiodarone , isosorbide mononitrate or glyceryl trinitrate , Digoxin , doxazosin, reserpine, amlodipine or indoramin , fluoxetine, tricyclic antidepressants, barbiturates, phenothiazines, haloperidol or monoamine oxide inhibitors (MAOIs) , ciclosporin , clonidine or ergotamine , ibuprofen or diclofenac , estrogens , prednisolone , rifampicin or erythromycin , cimetidine , ketoconazole , ephedrine or pseudoephedrine .

When not to Use

If you are allergic to carvedilol or any of the other ingredients of this medicine ; If you have been told you have very severe heart failure and you have fluid retention (swelling) which is being treated with injections of medicines into your veins (intravenously); If you have liver disease; If you have impaired conduction of the heart (or heart block) .

Precaution

Patients with a chronic obstructive pulmonary disease with a tendency towards bronchospasms who are not treated with oral or inhalation medicine should only be given carvedilol if the expected improvement outweighs the possible risk. Patients should be monitored closely in the initial phase, and titration of carvedilol and carvedilol dose should be reduced in case of bronchospasms.