TELSARTA D

SPECIFICATION

40/12.5mg , 80/12.5mg

Generics

Telmisartan + Hydrochlorothiazide

About

Telmisartan : Telmisartan is an orally effective and specific angiotensin II receptor subtype 1 (AT1) antagonist. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensinconverting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis. 

Indication

It is indicated for the treatment of hypertension.

Side Effects

 Dizziness Uncommon: Hypokalemia, anxiety, syncope, paraesthesia, vertigo, tachycardia, arrhythmias, hypotension, or thostatic hypotension, dyspnoea, diarrhea, dry mouth, flatulence, back pain, muscle spasms, myalgia, erectile dysfunction, chest pain and blood uric acid increase. Rare: Bronchitis, hyperuricemia, hyponatremia, depression, insomnia, sleep disorders, visual disturbance, vision blurred, respiratory distress.

Drug Interactions

Lithium , Digoxin , kaliuretic diuretics, laxatives, corticosteroids, ACTH, amphotericin, carbenoxolone, penicillin G sodium, salicylic acid and derivatives) , ACE inhibitors, potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium, cyclosporine or other medicinal p roducts such as heparin sodium) , quinidine, hydroquinidine, disopyramide), class III antiarrythmics (e.g, amiodarone, sotalol,dofetilide, ibutilide), some antipsychotics : (e.g., thioridazine, chlorpromazine, levomepromazine.

When not to Use

Telmisartan + Hydrochlorothiazide combination is contraindicated: In patients who are hypersensitive to this drug or any component of this product. - In patients with anuria or hypersensitivity to other sulfonamide-derived drugs, due to hydrochlorothiazide component in the preparation. - Refractory hypokalemia and hypercalcemia. - During second and third trimesters of pregnancy and lactation.

Precaution

Telmisartan + Hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.