RAMIPACE

SPECIFICATION

1.25mg , 2.5mg , 5mg & 10mg

Generics

Ramipril

About

Ramipril , inhibits the enzyme dipeptidylcarboxypeptidase I (synonyms: angiotensin-converting enzyme; kininase II). In plasma and tissue this enzyme catalyses the conversion of angiotensin I to the active vasoconstrictor substance angiotensin II, as well as the breakdown of the active vasodilator bradykinin. Reduced angiotensin II formation and inhibition of bradykinin breakdown lead to vasodilatation.

Indication

It is used: • To treat high blood pressure (hypertension) • To reduce the risk of you having a heart attack or stroke.

Side Effects

• Dry tickly cough, inflammation of your sinuses (sinusitis) or bronchitis, shortness of breath • Stomach or gut pain, diarrhoea, indigestion, feeling or being sick • Skin rash with or without raised area • Chest pain • Cramps or pain in your muscles.

Drug Interactions

Sacubitril/valsartan , (NSAIDs) such as ibuprofen or indometacin and aspirin) , ciclosporin , furosemide , triamterene, amiloride, potassium salts, trimethoprim alone or in combination with sulfamethoxazole .

When not to Use

Do not take ramipril : If you are allergic to ramipril, any other ACE inhibitor medicine or any of the ingredients of this medicine . Signs of an allergic reaction may include a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue ± If you have ever had a serious allergic reaction called “angioedema”. The signs include itching, hives (urticaria), red marks on the hands, feet and throat, swelling of the throat and tongue, swelling around the eyes and lips, difficulty breathing and swallowing.

Precaution

Generally, it is recommended to correct dehydration, hypovolaemia or salt depletion before initiating treatment (in patients with heart failure, however, such corrective action must be carefully weighed out against the risk of volume overload).