MISAR

SPECIFICATION

20mg , 40mg & 80mg

Generics

Telmisartan

About

Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation and renal reabsorption of sodium. Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis.

Indication

Telmisartan is indicated for the treatment of essential hypertension. It may be used alone or in combination with other antihypertensive agents.

Side Effects

Symptoms of infection (e.g., urinary tract infections including cystitis), upper respiratory tract infections including pharyngitis and sinusitis, abdominal pain, diarrhea, dyspepsia, eczema, arthralgia, back pain (e.g., sciatica), muscle spasms or pain in extremity, myalgia, chest pain and influenza-like illness.Uncommon: Anxiety, visual disturbance, vertigo, dry mouth, flatulence, hyperhidrosis and tendonitis.Rare: Stomach discomfort.

Drug Interactions

Digoxin , potassium-sparing diuretics, potassium supplements, salt substitutes , heparin, immunosuppresor (cyclosporine or tacrolimus), trimethoprim, ACE inhibitors, angiotensin II receptors antagonist, NSAIDS , lithium.

When not to Use

Telmisartan is contraindicated:- In patients who are hypersensitive to telmisartan or any component of the product.- During second and third trimesters of pregnancy and lactation.- In patients with biliary obstructive disorders.- In patients with severe hepatic impairment.- In patients with severe renal impairment.- In patients with hereditary fructose intolerance.

Precaution

Telmisartan is contraindicated:- In patients who are hypersensitive to telmisartan or any component of the product.- During second and third trimesters of pregnancy and lactation.- In patients with biliary obstructive disorders.- In patients with severe hepatic impairment.- In patients with severe renal impairment.- In patients with hereditary fructose intolerance.