LINCOCIN

SPECIFICATION

500Mg

Generics

Lincomycin HCl Monohydrate

About

Lincomycin inhibits bacterial protein synthesis by binding to the 23S RNA of the 50S subunit of the bacterial ribosome. Lincomycin is predominantly bacteriostatic in vitro.

Indication

The specific infections for which lincomycin is used include: ear, throat and lung infections; skin infections; bone and joint infections; and infections of the blood.

Side Effects

Skin and subcutaneous tissue disorders : Toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, dermatitis bullous, dermatitis exfoliative, erythema multiforme, rash, urticaria, pruritusInfections and infestations : Vaginal infection, pseudomembranous colitis, Clostridium difficile colitis .Blood and lymphatic system disorders : Pancytopenia, agranulocytosis, aplastic anemia, leukopenia, neutropenia, thrombocytopenic purpuraImmune system disorders : Anaphylactic reaction , angioedema, serum sicknessHepatobiliary disorders : Jaundice, liver function test abnormal, transaminases increasedRenal and urinary disorders : Renal impairment, oliguria, proteinuria, azotemiaCardiac disorders : Cardio-respiratory arrest Vascular disorders : Hypotension , thrombophlebitisEar and labyrinth disorders : Vertigo, tinnitusNeurologic disorders : Headache, dizziness, somnolence

Drug Interactions

Kanamycin, novobiocin and phenytoin , neuromuscular blocking medicines (muscle-relaxing medicines) .

When not to Use

Do not take Lincomycin if you have an allergy to: • Clindamycin or lincomycin • Any of the other ingredients listed.

Precaution

The use of Lincomycin may result in overgrowth of nonsusceptible organisms— particularly yeasts. Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation. When patients with pre-existing monilial infections require therapy with Lincomycin, concomitant antimonilial treatment should be given.