ERYTHROCIN

SPECIFICATION

250mg & 500mg

Generics

Bacterial Infection

About

Erythromycin exerts its antimicrobial action by binding to the 50S ribosomal sub-unit of susceptible microorganisms and suppresses protein synthesis. Erythromycin is usually active against most strains of the following organisms both in vitro and in clinical infections: Gram positive bacteria .

Indication

It is used to prevent and treat infections such as: • Throat and sinus infections • Chest infections, such as bronchitis and pneumonia • Ear infections • Mouth and dental infections • Eye infections • Skin and tissue infections, such as acne • Stomach and intestinal infections .

Side Effects

GI upset , Cholestatic jaundice , allergic reactions , reversible hearing loss , pancreatitis , cardiac effects , Myssthaenia like syndrome , Stevens-Johnson syndrome , toxic epidermal necrolysis , hepatotoxicity , hypotension , interstitial nephritis , hallucinations , chest pain , fever , malaise , QT Prolongation.

Drug Interactions

cisapride , statins protease inhibitors , oral contraceptives. , colchicine , cimetidine and omeprazole , clarithromycin, rifabutin, or rifampicin , fluconazole, ketoconazole and itraconazole , digoxin, quinidine or disopyramide , cilostazol , hexobarbitone, phenobarbital or midazolam , Anticoagulants e.g. warfarin, acenocoumarol and rivaroxaban, valproate, carbamazepine or phenytoin, theophylline ciclosporin or tacrolimus , bromocriptine zopiclone or triazolam/alprazolam.

When not to Use

You should not receive if you: • Have been told that you are allergic to erythromycin or other macrolide antibiotics such as clarithromycin or azithromycin or any of the other ingredients .

Precaution

Erythromycin is excreted principally by the liver, so caution should be exercised in administering the antibiotic to patients with impaired hepatic function or concomitantly receiving potentially hepatotoxic agents. Hepatic dysfunction including increased liver enzymes and/or cholestatic hepatitis, with or without jaundice, has been infrequently reported with erythromycin.