CYROCIN

SPECIFICATION

250mg & 500mg

Generics

Ciprofloxacin HCl

About

It acts via inhibition of bacterial DNA gyrase (topoisomerase, which is essential in the reproduction of bacterial DNA), ultimately resulting in interference with DNA function. Ciprofloxacin is highly active against a wide range of Gram-positive and Gram-negative organisms and has shown activity against some anaerobes.

Indication

It is used to treat : • Lower respiratory tract infections due to Gram-negative bacteria• Acute exacerbation of chronic sinusitis especially if these are caused by Gram-negative bacteria• Urinary tract infections• Genital tract infections

Side Effects

Nausea, Diarrhoea , Mycotic superinfections, Eosinophilia, Anorexia, Psychomotor hyperactivity / agitation, Headache, Dizziness, Sleep disorders, Taste disorders, Vomiting, Gastrointestinal and abdominal pains, Dyspepsia, Flatulence, Increase in transaminases, Increased bilirubin, Rash, Pruritus, Urticaria, Musculoskeletal pain (e.g. extremity pain, back pain, chest pain), Arthralgia, Renal impairment, Asthenia, Fever, Increase in blood alkaline phosphatase.

Drug Interactions

Theophylline, clozapine, tacrine, ropinirole, tizanidine, duloxetine , Chelation complex formulation like , calcium, magnesium, aluminum or iron), polymeric phosphate binders (e.g., sevelamer), sucralfate or antacids and highly buffered drugs (e.g., didanosine ) , caffeine or pentoxifylline (oxpentifylline) , Phenytoin , Glyburide/Glibenclimide , Warfarin , Probencid , Methotrexate , Metoclopramide , Omeprazole , Cyclosporin , Sildenafil.

When not to Use

Ciprofloxacin is contraindicated in patients with a history of hypersensitivity to ciprofloxacin, any member of the quinolone class of antimicrobial agents or any of the product components. - Concomitant administration with tizanidine is contraindicated.

Precaution

Cases of hepatic necrosis and life-threatening hepatic failure have been reported with ciprofloxacin. In the event of any signs and symptoms of hepatic disease (such as anorexia, jaundice, dark urine, pruritus, or tender abdomen), treatment should be discontinued.