Description
Description
SPECIFICATION
80/480Mg
Generics
Artemether , Lumefantrine
About
Both components Artemether/ Lumefantrine have their own action site in the malarial parasite. The presence of the endoperoxide bridge in Artemether (generating single oxygen and free radicals, those are very cytotoxic to the plasmodia) appears to be essential for antimalarial activity
Indication
Used in the treatment of Malaria.
Side Effects
Palpitations, headache, dizziness, abdominal pain, anorexia, vomiting, nausea, arthralgia, mylagia, asthenia, fatigue, sleep disorders.Common: Amnesia, paraesthesia, diarrhea, pruritus, rash, cough, electrocardiogram QT prolongation, gait disturbances, insomia.Uncommon: Liver function test increased, clonus, hypoesthesia, ataxia, somnolence.
Drug Interactions
CYP3A4 inhibitors (e.g. erythromycin, ketoconazole, itraconazole, cimetidine, HIV protease inhibitors, etc.) , CYP2D6 inhibitors (e.g. flecainide, metoprolol, imipramine, amitryptyline, clomipramine, etc.) , Mefloquine.
When not to Use
It is contraindicated to those patients which have a history of hypersensitivity to Lumefantrine.
Precaution
Due to limited data on safety and efficacy, Artemether+Lumefantrine should not be given concurrently with any other anti-malarial agent unless there is no other treatment option.