Clobederm Cream

SPECIFICATION

10Gm

Generics

Clobetasol Propionate

About

Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators.

Indication

It is used to help reduce the redness and itchiness of certain skin problems. These skin problems include:• Frequently relapsing eczema• Psoriasis (thickened patches of inflamed, red skin, often covered by silvery scales), excluding widespread plaque psoriasis• Lichen planus (a skin disease that causes itchy, reddish-purple, flat-topped bumps on the wrists, forearms or lower legs)• Discoid lupus erythematosus (a disease of the skin most often affecting the face, ears and scalp causing scarring and increased sensitivity of the affected skin to sunlight)• Dermatitis and other skin conditions that have not responded to milder steroid creams or ointments .

Side Effects

 a feeling of burning, pain, irritation or itching where the ointment is applied.Uncommon (may affect up to 1 in 100 people)• skin thinning, stretch marks may develop. • blood vessels under the surface of your skin may become more noticeable. Very Rare (may affect up to 1 in 10,000 people)Use of Dermovate for a long period of time, or use under an airtight dressing, may cause the following symptoms:• increased weight • moon face, rounding of the face • obesity • skin thinning • skin wrinkling • skin dryness • changes to the colour of your skin • increased body hair • hair loss/lack of hair growth/damaged looking hair.

Drug Interactions

Ritonavir and itraconazole

When not to Use

Do not use : • If you are allergic (hypersensitive) to clobetasol propionate or any of the other ingredients of this medicine .• On a child under 1 year of age• To treat any of the following skin problems, it could make them worse:- Acne - severe flushing of skin on and around your nose (rosacea) - spotty red rash around your mouth (perioral dermatitis) - itching around your anus or genitals (penis or vagina) - infected skin (unless the infection is being treated with an anti-infective medicine at the same time) - itchy skin which is not inflamed - widespread plaque psoriasis, except single lesions.

Precaution

If you are applying to thin skin such as the face, as It may cause skin thinning. Use on the face should be limited to 5 days. Dressings or bandages should not be used on the face where the ointment is applied.