ALDACTONE A

SPECIFICATION

25Mg

Generics

Spironolactone

About

It is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent, sodium-potassium exchange site in the distal convoluted renal tubule. It causes increased amounts of sodium and water to be excreted, while potassium loss is minimized. Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule.

Indication

It is used: • To treat essential hypertension (high blood pressure with an unknown cause) • To treat oedematous disorders (swelling with fluid), including congestive cardiac failure.

Side Effects

 Blood and lymphatic system disorders: Leukopenia (including agranulocytosis), thrombocytopenia, anemia. Gastrointestinal disorders: Diarrhea and cramping, gastric bleeding, gastritis, nausea, ulceration, vomiting. General disorders and administration site conditions: Malaise. ATAXIA Hepatobiliary disorders: Abnormal hepatic function.

Drug Interactions

Alcohol, barbiturates or narcotics , Antipyrine , Cholestyramine/ Ammonium Chloride , Corticosteroids, and adrenocorticotropic hormone (ACTH) , Diuretics and Antihypertensives , Eplerenone , Heparin, low molecular weight heparin , Drugs known to cause hyperkalemia , Lithium , Norepinephrine , Digoxin , Non-Steroidal Anti-Inflammatory Drugs

When not to Use

Do not take spironolactone if: • You are allergic to spironolactone or any of the other ingredients of this medicine • You cannot pass urine • You have severe kidney disease .

Precaution

It should be used with caution in patients with impaired hepatic function because minor alterations of fluid and electrolyte balance may precipitate hepatic coma.