DAONIL

SPECIFICATION

5mg

Generics

Glibenclamide

About

Both in healthy people and in patients with non-insulin dependent (type 2) diabetes mellitus, glibenclamide lowers blood glucose concentration by stimulating insulin release from the betacells of the pancreas. Glibenclamide is also reported as having extrapancreatic effects: it reduces hepatic glucose production and enhances insulin binding and insulin sensitivity in peripheral tissues.

Indication

• Diabetes

Dosage

According to HBA 1c level

Side Effects

Headache, ravenous hunger, nausea, vomiting, lassitude, sleepiness, disordered sleep, restlessness, aggressiveness, impaired concentration, alertness and reactions, depression, confusion, speech disorders, aphasia.

Drug Interactions

Bosentan

When not to Use

It must not be used: In patients with insulin-dependent (type 1) diabetes mellitus (for example diabetics with a history of ketoacidosis) ; In treatment of diabetic ketoacidosis ; In treatment of diabetic precoma or coma ; In patients with serious renal dysfunction ; In patients with serious hepatic dysfunction ; In patients hypersensitive to glibenclamide , In patients hypersensitive to any of the excipients ; In pregnant women ; In breast feeding women ; In patients treated with bosentan .

Precaution

Treatment of patients with G6PD-deficiency with sulfonylurea agents can lead to hemolytic anaemia. Since glibenclamide belongs to the class of sulfonylurea agents, caution should be used in patients with G6PD-deficiency and a nonsulfonylurea alternative should be considered.