ICEF

SPECIFICATION

400MG

Generics

Cefixime Trihydrate

About

Like other cephalosporins, cefixime exhibits its bactericidal action by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis.

Indication

Cefixime is indicated in the treatment of the following infections when caused by susceptible strains of the designated microorganisms: - Uncomplicated urinary tract infections - Otitis media - Pharyngitis and tonsillitis - Acute bronchitis and acute exacerbations of chronic bronchitis - Uncomplicated gonorrhea (cervical/urethral).

Dosage

 Once daily for 7 days.

Side Effects

Diarrhea (if severe diarrhea occurs, cefixime should be discontinued), changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting, Headache, dizziness, seizures , Transient rises in liver transaminases,alkaline phosphatase and jaundice , elevation of serum amylase.

Drug Interactions

Anticoagulants , Carbamazepine , probenecid.

When not to Use

Cefixime is contraindicated in: Patients with hypersensitivity to any component of this medication. Patients with known allergy to the cephalosporin group of antibiotics.

Precaution

Cephalosporins should be given with caution to penicillinsensitive patients, as there is some evidence of partial cross-allergenicity between the penicillins and cephalosporins.